SOUTH SAN FRANCISCO, Calif., Oct. 31, 2022 (GLOBE NEWSWIRE) — Cytokinetics, Incorporated (Nasdaq: CYTK) today announced three upcoming poster presentations at the 2022 American Heart Association Scientific Sessions taking place in Chicago , Illinois, Nov. 5-2022 – Nov. 7, 2022. Poster presentations include an analysis of patients hospitalized for heart failure with severely reduced ejection fraction from the Get With The Guidelines®-Heart Failure Registry as well as two analyzes from GALACTIC -HF (Global Approach to Lowering Adverse Cardiac Outcomes Through Improving Contractility in Heart Failure), one relating to healthcare resource utilization, early benefits, and cost for North American patients most likely to benefit of treatment with mecarbil omecamtiv, and one assessing gender differences in GALACTIC-HF.

Title: Clinical profile of patients hospitalized for heart failure with severely reduced ejection fraction: extract from the GWTG-HF register

Presenter: Stephen Greene, MD, Assistant Professor, Division of Cardiology, Advanced Heart Failure and Transplantation, Duke University Medical Center, Duke Clinical Research Institute

Date: November 5, 2022

Session Title: Heart Failure Across the EF Spectrum

Card number: 2195

Session time: 3:00 p.m. – 4:00 p.m. CT

Location: Zone 2‚ Science and Technology Room‚ Level 3

Title: Early Health Care Resource Utilization, Benefits, and Costs for North American Patients with HFrEF Most Likely to Benefit from Omecamtiv Mecarbil

Presenter: Nihar R. Desai, MD, MPH, Associate Professor of Medicine, Associate Chief, Cardiovascular Medicine, Yale School of Medicine, Center for Outcomes Research and Evaluation

Date: November 7, 2022

Session Title: Management of Heart Failure in Population and Outcome Research

Card number: 2106

Session Time: 11:00 a.m. – 12:00 p.m. CT

Location: Zone 2‚ Science and Technology Room‚ Level 3

Title: Gender differences in heart failure with reduced ejection fraction in the GALACTIC-HF trial

Presenter: Maria Pabon Porras, MD, Cardiovascular Division, Brigham and Women’s Hospital and Harvard Medical School

Date: November 7, 2022

Session Title: Management of Heart Failure in Population and Outcome Research

Card number: 2103

Session Time: 11:00 a.m. – 12:00 p.m. CT

Location: Zone 2‚ Science and Technology Room‚ Level 3

About Cytokinetics

Cytokinetics is a late-stage biopharmaceutical company focused on the discovery, development and commercialization of first-in-class muscle activators and cutting-edge muscle inhibitors as potential treatments for debilitating diseases in which muscle performance is compromised. As a leader in muscle biology and the mechanics of muscle performance, the company develops small molecule drug candidates specifically designed to impact muscle function and contractility. Cytokinetics prepares for potential commercialization of mecarbil omecamtiv, its heart muscle enhancer, following positive results from GALACTIC-HF, a large international Phase 3 clinical trial in patients with heart failure. Cytokinetics also develops to affirma next-generation cardiac myosin inhibitor, currently the subject of SEQUOIA-HCM, the phase 3 clinical trial of to affirm in patients with symptomatic hypertrophic obstructive cardiomyopathy (HCM). Aficamten is also being evaluated in non-obstructive HCM in Cohort 4 of the Phase 2 clinical trial, REDWOOD-HCM. Cytokinetics also develops relative, an investigational fast skeletal muscle troponin activator, which is currently undergoing COURAGE-ALS, a Phase 3 clinical trial in patients with amyotrophic lateral sclerosis (ALS). Cytokinetics continues its 20+ year history of pioneering innovation in muscle biology and related pharmacology focused on muscle dysfunction diseases and muscle weakness conditions.

For more information about Cytokinetics, visit www.cytokinetics.com and follow us on Twitter, LinkedIn, Facebook and YouTube.

Forward-looking statements

This press release contains forward-looking statements for the purposes of the Private Securities Litigation Reform Act of 1995 (the “Act”). Cytokinetics disclaims any intention or obligation to update these forward-looking statements and claims the protection of the safe harbor of law for forward-looking statements. Examples of such statements include, but are not limited to, statements relating to one of our other clinical trials, statements relating to the potential benefits of mecarbil omecamtiv or one of our other drug candidates. the research and development activities of Cytokinetics; the design, timing, results, significance and utility of preclinical and clinical results; and the properties and potential benefits of other Cytokinetics drug candidates. These statements are based on management’s current expectations, but actual results may differ materially due to various risks and uncertainties, including, but not limited to, potential difficulties or delays in development, testing, regulatory approvals for the initiation of testing, development or sale of products or the manufacture or production of Cytokinetics’ drug candidates that could slow or prevent clinical development or product approval; Cytokinetics’ drug candidates may have undesirable side effects or inadequate therapeutic efficacy; the FDA or foreign regulatory agencies may delay or limit Cytokinetics’ ability to conduct clinical trials; Cytokinetics may not be able to obtain or maintain patent or trade secret protection for its intellectual property; standards of care may change, rendering Cytokinetics drug candidates obsolete; and competing products or alternative therapies may be developed by others for the treatment of indications that Cytokinetics’ drug candidates and potential drug candidates may target. For more information regarding these and other risks associated with Cytokinetics’ business, investors should consult Cytokinetics’ filings with the Securities and Exchange Commission.

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Contact:

Cytokinetics

Diane Weiser

Senior Vice President, Corporate Communications, Investor Relations

(415) 290-7757